Topical ointments such as Flammazine are commonly used for the treatment of superficial,Īnd partial thickness burns to keep the wound environment in moist condition, decrease pain, and prevent Partial-thickness burns usually heal within 2 weeks unless complications such as infection or chronicĭiseases occur. That good hydration is an important external factor responsible for optimal wound healing. There is, however, more recent evidence in literature Perfusion pressure results in delayed healing as well. Local wound factors such as infection and prolonged periods of pressure greater than tissue ![]() Factors adversely affecting wound healing include advancedĪge of patients, poor nutrition, smoking, diabetes, anemia, obesity, cancer, ischemia, uremia andĭenervation. Healing involves three processes: epithelialization,Ĭonnective tissue deposition, and contraction. In tissue regeneration but rather in tissue restoration. Wound healing is a complex series of events characterized by inflammation however, it does not culminate Health Technology Assessment Section (MaHTAS)Īvailable at the following website: moh.gov EXECUTIVE SUMMARY Please contact: if you would like further information. Reported since completion of this review. Additionally, other relevant scientific findings may have been While effort has been made to do so, this document may not fully reflect all scientific It is not subjected to an external review process. Restricted reviews from analysis of pertinent literature, on expert opinion and / or Technology review is a brief report, prepared on an urgent basis, which draws on 29:S19–S36.MEBO BURN OINTMENT HEALTH TECHNOLOGY ASSESSMENT UNIT MEDICAL DEVELOPMENT DIVISION MINISTRY OF HEALTH MALAYSIA SERIAL NO 015 / HEALTH TECHNOLOGY ASSESSMENT SECTION MEDICAL DEVELOPMENT DIVISION MINISTRY OF HEALTH MALAYSIA 015/ Management of chronic wounds: diagnosis, preparation, treatment, and follow-up. Gupta S, Andersen C, Black J, de Leon J, Fife C, Lantis Ii JC, Niezgoda J, Snyder R, Sumpio B, Tettelbach W, et al. BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway. Guo C, Wang L, Zhao Y, Jiang B, Luo J, Shi D. Nerve growth factor and substance P may be involved in moist exposed burn ointment-mediated chronic refractory wound healing. Epicatechin gallate protects HBMVECs from ischemia/reperfusion injury through ameliorating apoptosis and autophagy and promoting neovascularization. 21:20–22.įu B, Zeng Q, Zhang Z, Qian M, Chen J, Dong W, Li M. Role of MEBO (moist exposed burn ointment) in the treatment of Fournier’s gangrene. Discussion and conclusions: In this study, we discussed the molecular mechanism of MEBT/MEBO promoting the repair of diabetic ulcer wounds through autophagy and PI3K-Akt-mTOR signalling pathway, which provides a new way for drug design in the future.ĭiabetes PI3K–Akt–mTOR fibroblasts traditional Chinese medicine wound healing rate.Īl-Meshaan M, Abdul Hamid M, Quider T, Al-Sairafi A, Dham R. ![]() On Day 11, the expression levels in each group began to decline. The mRNA and protein expression of PI3K, Akt and mTOR in each group reached the peak on Day 5, the levels in the MEBO group were the highest ( F = 18.43, 19.97, 15.36, p < 0.05). ![]() The morphology of autophagosomes ranged large to small, which was the most obvious in the MEBO group. Results: The healing time in the control group was the shortest, no statistically significant difference was found between the MEBO and the Kangfuxin group ( p = 0.76). Wound healing was dynamically observed and wound tissues were collected at five time points for pathological examination, autophagosome and the expression of PI3K, Akt and mTOR. All rats underwent full-thickness skin resection in the back. Materials and methods: Eighty male Wistar rats were randomly assigned to control ( n = 20) and diabetic group induced by intraperitoneal injection of STZ ( n = 60), which were further randomly assigned to MEBO, Kangfuxin and model groups ( n = 20 each). Objective: To explore the mechanism of moist exposed MEBT/MEBO promoting diabetic wound repair. Autophagy has been proved to be closely related with wound healing, so MEBO/MEBT is hypothesized to promote diabetic wound healing by regulating autophagy. Context: Burn therapy (MEBT)/moist exposed burn ointment (MEBO) is an effective traditional Chinese medicine method to treat diabetic wound, but the mechanism is unclear.
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